Inspired by the viral New York Magazine article "The Hustlers at Scores," Hustlers follows a crew of savvy strippers who band together to turn the tables on their Wall Street clients.
Starting in 2007, we meet experienced exotic dancer Ramona (Jennifer Lopez) and newcomer Destiny (Constance Wu). Ramona takes Destiny under her wing and introduces her to the life of an exotic dancer, showing her how the game works. She also learns that the group of strippers she's become a part of not only dance, but hustle their way into the pockets of their wealthy clients.
However, after the 2008 Wall Street crash, attendance at the club drops off and the dancers struggle to earn money. They devise a scam to coerce potential clubgoers to spend huge amounts of money at the club, with the women getting a large cut of the profits. But this scheme doesn't work well in the long run.